On Sept. 27, 2024, a study that evaluated the structural and functional connectivity correlates of fatigue in post-COVID syndrome (PCS) suggested a role of central nervous system involvement in the pathophysiology of fatigue.

One-hundred and twenty-nine patients were recruited and evaluated with fatigue, neuropsychological, and subjective cognitive complaints assessments. Fatigue was present in 86 % of patients, and was highly correlated to subjective cognitive complaints.

The study, published in Psychiatry Research, pointed out the relevance of the multidisciplinary assessment of post-COVID syndrome patients with subjective cognitive complaints, in order to unravel the symptomatology beneath the patient’s complaints.