On May 23, 2017, the University of Chicago Medicine announced receipt of a $100 million donation by Craig Duchossois, his wife, Janet, and The Duchossois Family Foundation. The institute supports research and interventions based on how the human immune system, microorganisms and genetics interact to maintain health.

The Duchossois Family Foundation and UChicago Medicine spans more than 40 years, inspired by the care that matriarch Beverly Thrall Duchossois received when she was treated for cancer in the late 1970s.